TaKaRa LA Taq DNA Polymerase combines Taq DNA polymerase and a DNA proofreading polymerase, with 3’?5’ exonuclease activity, to enable PCR amplification of very long DNA templates (long-range PCR). This mixture of enzymes allows for long and accurate (LA) PCR of targets from a variety of templates, including genomic DNA. This item Cat# RR002M is supplied with optimized LA PCR Buffer II (with added Mg2+) and dNTPs. The presence of the proofreading polymerase increases fidelity as compared to Taq polymerase alone. Using the LA Taq long-PCR system, routine extensions of 20 kb are possible, and products of up to 48 kb can be obtained for some templates.