Description

Citrullus Colocynthus is a desert plant, distributed in di?erent parts of the world from Asia to Europe, used traditionally as a purgative and analgesic. It is also popular in PM for its antidiabetic e?ects. The e?ciency of C. Colocynthus on diabetes mellitus is evaluated in multiple studies. C. Colocynthus can signi?cantly improve fasting blood glucose, glycated hemoglobin, and lipids of patients with T2DM. The topical use of C. Colocynthus drops also showed improvement in pain and nerve function of patients with painful diabetic polyneuropathy. In Ayurveda Citrullus Colocynthus used in multiple ethno pharmacologic studies from different part of the world as a traditional remedy for a variety of diseases including gastrointestinal, musculoskeletal, neurological, cardiovascular, and respiratory disorders also, diabetes mellitus is known as the most popular traditional indication of Citrullus Colocynthus. Beta-pyrazol-1-yl-alanine and saponin fractions are the main insulin tropic active ingredients of C. Colocynthus. It’s inhibitory effect on glucose absorption, gluconeogensis, and glycogenolysis.